• Users Online: 62
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2015  |  Volume : 15  |  Issue : 1  |  Page : 8-13

The third ventricle in Kaolin-induced hydrocephalus in juvenile rats


Department of Anatomy and Cell Biology, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria

Correspondence Address:
O A Ayannuga
Department of Anatomy and Cell Biology, College of Health Sciences, Obafemi Awolowo University, Ile-Ife
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1596-4078.171376

Rights and Permissions

Background: The enlargement of the third ventricle in hydrocephalus has mechanical effects on the structures that form its boundaries such as thalamus and hypothalamus. This may explain some of the symptoms associated with hydrocephalus. While the lateral ventricles had been widely investigated in hydrocephalus, studies of the third ventricle are sparse. The present study set out to investigate the ependymal lining and the direction of enlargement of the third ventricle in hydrocephalus. Materials and Methods: Three-week old rats were divided into 6 groups (A-F) of five each. Groups A-C were experimental and sacrificed after 1, 4, and 8 weeks of induction, respectively, while groups D-F served as age-matched controls. Hydrocephalus was induced by intracisternal injection of 0.04 ml of 200 mg/ml kaolin suspension. Rats were sacrificed by cervical dislocation and approximately 1 mm thick coronal brain slices were obtained at optic chiasma level. Slices were fixed in 10% formal saline, processed and stained with hematoxylin and eosin. Results: Compared with corresponding control rats, the lateral ventricle width was significantly increased in 1 and 8 weeks postinduction experimental rats (P = 0.005 and 0.012 respectively), while supero-inferior distance of the experimental third ventricle was significantly lower at 1-week postinduction (P < 0.001), and increased at 8-week postinduction (P = 0.025). However, differences in the inter-thalamic distance at 1- and 8-week were not statistically significant (P = 0.14 and 0.224, respectively). Ependymal detachment was patchy and generalized at 1 and 4 weeks, respectively. Thinned and detached ependymal lining were noted 8-week postinduction. Conclusion: Kaolin-induced hydrocephalus caused early ependymal detachment in the third ventricle of rats, while ependymal thinning and villi sparing was a feature of chronicity. The third ventricle enlarges in the supero-inferior direction, this might explain some symptoms associated with hydrocephalus.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1487    
    Printed127    
    Emailed1    
    PDF Downloaded15    
    Comments [Add]    

Recommend this journal