• Users Online: 64
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 16  |  Issue : 1  |  Page : 6-9

Cytokines responses to human African trypanosomiasis infection in Abraka, Nigeria


1 Department of Zoology, Ambrose Alli University, Ekpoma, Nigeria
2 Department of Medical Microbiology and Parasitology, College of Health Sciences, Delta State University, Abraka, Nigeria

Correspondence Address:
C Isaac
Department of Zoology, Ambrose Alli University, Ekpoma
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1596-4078.189972

Rights and Permissions

Background: The staging of human African trypanosomiasis (HAT) has been greeted with different benchmarks ranging from white blood cell counts to the use of immune component profiles across regions. Objective: The aim of this study was to analyze an array of cytokines to identify potential markers that could be used in the staging of HAT in Nigeria. Methods: Sera and cerebrospinal fluid (CSF) of 35 HAT seropositives from Abraka, Delta State, Nigeria were subjected to cytokines (interleukin-10 [IL-10], tumor necrosis factor-α, IL-1α, IL-7, and IL-13) analysis using enzyme-linked immunosorbent assay. Welch t-test and Tukey analysis of variance were used to analyze the data. Results: Comparing mean cytokine levels of weakly, moderately, and strongly positives and between as early and late stages results showed significantly depressed CSF levels of IL-1α and IL-7 while IL-10 was significantly elevated in the strongly positives as well as in the late stage. Conclusion: We strongly suggest that IL-10 could be playing a key role in the immuno-pathology of HAT, thus should be considered a biomarker for the late stage.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed344    
    Printed21    
    Emailed0    
    PDF Downloaded8    
    Comments [Add]    

Recommend this journal